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State Key Laboratory of Phytochemisty and Plant Resources in Southwest China
CHENG Yongxian's Group
CHEN Jijun's Group
HAO Xiaojiang's Group
LIU Jikai's Group
LUO Xiaodong's Group
QIU Minghua's Group
ZENG Ying's Group
SUN Handong's Group
TAN Ninghua's Group
ZHANG Yingjun's Group
ZHAO Qinshi's Group
LUO Huairong's Group
LI Yan's Group
LI Shenghong's Group
YANG Yurong's Group
XIA Chengfeng's Group
ZHAO Jinhua's Group
QIN Hongbo's Group
WU Bin's Group
XU Gang's Group
ZHOU Jun's Group
LIU Haiyang's Group
XIONG Wenyong's Group
HU Kaifeng's Group
Location: Home > Our Groups > State Key Laboratory of Phytochemisty and Plant Resources in Southwest China > XU Gang's Group > Major Research Achievements
Research Progress

1. Studies on diterpenoid constituents and their activities from plants of the genus Salvia:  

Salvia, which includes 700~1050 species worldwide, is largest genus of the Labiatae family. The name “Salvia” comes from the Latin word “Salvare”, which means “to heal”. Since ancient times, many Salvia species, such as S. miltiorrhiza, S. prionitis, S. divinorum, and S. officinalis, have been used as folk medicine through-out the world for more than sixty different ailments ranging from aches to epilepsy, and mainly to treat colds, bronchitis, tuberculosis, hemorrhage, menstrual disorders, and cardiovascular diseases. are all used as folk medicines in the different area. 

The chemical constituents of Salvia species have been extensive studied for more than seventy years. The first investigation on Salvia diterpenoids can be traced back to 1928. During the last several decades, the diterpenoids from Salvia species and their biological activities have been studied extensively by the scientists allover the world, and more than 600 new diterpenoids including abietanes, clerodanes, icetexanes, labdanes, primranes, and kauranes with different oxygenations and cleavage patterns have been isolated and characterized. 

Hengduanshan mountains is one of the three distribution centers of this genus with extremely rich resources and variety habitats as well as complex topography. During the past 12 years, we have investigated the chemical constituents of 12 Salvia plants; totally 338 isolates including 76 new ones and 4 new carbon skeletons were isolated and characterized, and 12 SCI papers about the terpenoid studies of Salvia plants have been published. In addition, several isolates were found to possess significant activities for antitumor and antidiabitic. 

2. Studies on Polycyclic Polyprenylayed Acylphloroglucinols (PPAPs) and their functions. 

Natural polycyclic polyprenylated acylphloroglucinols (PPAPs), with a highly oxygenated and densely substituted bicyclo[3.3.1]nonane-2,4,9-trione or other related core structures decorated with prenyl or geranyl side chains, were a special class of complex natural products that only isolated from plants of the family Guttiferae so far. This kind of metabolites showed a wide variety of biological activities such as antitumor, antimicrobial, anti-HIV, antioxidant, and especially in the CNS as modulators of neurotransmitters associated with neuronal damage and depression. In recent years, the fascinating chemical structures and intriguing biological activities of PPAPs have attracted widespread attention from phytochemical, organic synthetical, and pharmacological endeavors. 

Since 2008, our team has completed chemical constituent studies of 10 Guttiferae plants, totally 218 compounds including 127 new compounds were isolated. More than 10 SCI papers have been published by our team in this field. And several isolates have been tested to possess obvious antitumor activities.  

3. Medical ethnobotany 

With the traditional life style disappearing, traditional medicine is faced with the risk of losing, as the main part of traditional medicine, medicinal plants used in different ethnic group urgent need to in in-depth systematic document. This research team has implemented four projects on ethnobotanical field studies that focused on medicinal plant and related traditional knowledge in Three Parallel Rivers in Northwest Yunnan since 2005. After eight - year efforts, as a case study, called as "Ludian Model" by the international medias, one of solution approaches have been provided for the issue between the community and the conservation area for the Himalayan region of medicinal plant conservation and related traditional medicine knowledge. From project implementation, this team member had the further understanding and improving with diversity richness of medicinal plants and the value of traditional medicine knowledge in Northwest Yunnan. Published seven papers and three of them are SCI papers. Some foundation was established for further study with medicinal plants and related traditional knowledge. 

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