Investigation on the Chemical and Bioactivities of Schisandraceae Species

   The program has investigated 16 plants of the genus Schisandra and Kadsura. About 100 novel highly oxygenated rearranged triterpenoids and nortriterpenoids with new skeleton were discovered. Among them, several ones have been found to show significant anti-HIV bioactivity with minimal toxicity. This result has attracted much attention in the world. The researchers will continue to isolate more novel, new skeletal types or biosynthetic precursors and find more potential bioactivities from this genus. These series of novel triterpenoids and nortriterpenoids isolated from the family Schisandraceae greatly enriched the contents of natural occurred triterpenoid chemistry. The program was carried out by Prof. Sun Han-Dong and his co-workers.



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