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Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans
source:CHEMICAL & PHARMACEUTICAL BULLETIN     author:Jiang, Meng-Yuan; Zhang, Ling; Dong, Ze-Jun; et.     2010-04-09

  Three new metabolites, vibralactones D-F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of I was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound I showed weak inhibitory activities against isozymes of 11 beta-hydroxysteroid dehydrogenases (HSD) with IC50 values of 85.7 mu M (human HSD1), 295.2 mu M (mouse HSD1), and 87.1 mu M (human HSD2).


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