The project started in 1991 and it has successively received financial support from 12 projects sponsored by the KIB State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Natural Science Foundation and National Natural Science Foundation of China with total fund amounting to RMB 700,000 yuan. Plant cyclopeptide is a very important plant metabolite and also a new ...
In collaboration with State Key Laboratory of Medical Genomics in Shanghai Jiao Tong University, Shanghai Institutes for Biological Sciences in CAS, and Rui Jin Hospital, Prof. Sun Handong, academician of CAS, observed significant apoptosis of t (8; 21) chromosome translocation through NF-κB and MAPK pathways, concomitant with caspase-3 activation. AML1-ETO oncoprotein was degraded in pa...
The program has investigated 16 plants of the genus Schisandra and Kadsura. About 100 novel highly oxygenated rearranged triterpenoids and nortriterpenoids with new skeleton were discovered. Among them, several ones have been found to show significant anti-HIV bioactivity with minimal toxicity. This result has attracted much attention in the world. The researchers will continue to isolate ...
This program carried out systematic studies on chemical components and biological activity of some higher fungi in Yunnan. Studies on chemical components of over 50 kinds of wild higher fungi and screening of medicinal activity of higher-fungi fruit bodies and fermentation broth extract have been completed. Through this study, over 300 kinds of compounds have been identified, 100 of which ...
In Sep. 2007, a post-evaluation was carried out on the CAS 'ninth-five' key and special-support program, R&D of New Natural Drugs against Several Serious Diseases, co-chaired by Prof. Hao Xiaojiang from KIB, Prof. Ding Jian from Shanghai Institute of Materia Medica, CAS and Prof. Li Boliang from Shanghai Institute of Biochemistry, CAS. The post-evaluation conducted by CAS Program Evaluatio...
Plants have evolved multiple mechanisms to selectively suppress pathogens by production of secondary metabolites. Therefore, direct selections for antiviral compounds from plants can be used to identify new agents with potent antiviral activity but not toxic to hosts. In collaboration with CAS Institute of Microbiology, Institute for Viral Disease Control and Prevention, Chinese Center for...
